Tuesday, October 1, 2013
First - What is biological therapy? Biological therapy (also called immunotherapy, biological response modifier therapy, or biotherapy) uses the body's immune system to fight cancer. The cells, antibodies, and organs of the immune system work to protect and defend the body against foreign invaders, such as bacteria or viruses. Physicians and researchers have found that the immune system might also be able to both determine the difference between healthy cells and cancer cells in the body, and to eliminate the cancer cells. For the cancer virus, there are as many variations of the “disease” as there are various types of body organs. Equally, and as a corollary then, there is one cure with as many variations as there are cancers due to the patient’s white blood cell and it’s ability to be amended, modified, translated or re-engineered as there are T-Cells and B-Cells to create a vaccine. Initially it is by blood group, then by type of organ (hence biopsies) to create the vaccine then by DNA group. Some vaccines will be ubiquitous to many, others will be a more specialized boutique vaccines - known as Bio-Logics. Biological therapies are designed to boost the immune system “to clue it in other words”, either directly or indirectly, by assisting in the following “bio-logical” process: · making cancer cells more recognizable by the immune system, and therefore more susceptible to destruction by the immune system · boosting the killing power of immune system cells · changing the way cancer cells grow, so that they act more like healthy cells · stopping the process that changes a normal cell into a cancerous cell · enhancing the body's ability to repair or replace normal cells damaged or destroyed by other forms of cancer treatment, such as chemotherapy or radiation · preventing cancer cells from spreading to other parts of the body. The immune system includes different types of white blood cells - each with a different way to fight against foreign or diseased cells, including cancer: · Lymphocytes - white blood cells, including B cells, T cells, and NK cells. · B cells - produce antibodies that attack other cells. · T cells - directly attack cancer cells themselves and signal other immune system cells to defend the body. · Natural killer cells (NK cells) - produce chemicals that bind to and kill foreign invaders in the body. · Monocytes - white blood cells that swallow and digest foreign particles. These types of white blood cells - B cells, T cells, natural killer cells, and monocytes - are in the blood and thus circulate to every part of the body, providing protection from cancer and other diseases. Cells secrete two types of substances: antibodies and cytokines. Antibodies respond to (harmful) substances that they recognize, called antigens. Specific (helpful) antibodies match specific (foreign) antigens by locking together. Cytokines are proteins produced by some immune system cells and can directly attack cancer cells. Cytokines are "messengers" that "communicate" with other cells. What are the different types of biological therapies? There are many different types of biological therapies used in cancer treatment, including the following: · non-specific immunomodulating agents Non-specific immunomodulating agents are biological therapy drugs that stimulate the immune system, causing it to produce more cytokines and antibodies to help fight cancer and infections in the body. Fighting infection is important for a person with cancer. · biological response modifiers (BRMs) Biological response modifiers (BRMs) change the way the body's defenses interact with cancer cells. BRMs are produced in a laboratory and given to patients to: o boost the body's ability to fight the disease. o direct the immune system's disease fighting powers to disease cells. o strengthen a weakened immune system. BRMs include interferons, interleukins, colony-stimulating factors, monoclonal antibodies, cytokine therapy, and of course bio-cellular vaccines: · vaccine therapy. Vaccine therapy is perhaps the primary new biological therapy to destroy cancer cells and related tumours by using the body’s own immune system through the use of modified, translational, enhancements, re-engineered white blood cells. For many this already works on its own, for others it needs a friendly nudge in the right direction and for others it’s a re-educational process with the use of the patient’s own T-Cells or in some cases B-Cells. The obvious benefit of a vaccine therapy has been proven time and time again. After all, cancer is simply an oncolvirues and should be treated as such. Again, and as with so many infectious diseases, vaccines are given A. before the disease develops, and of course B. after the disease develops. Cancer vaccines, however, are given after the disease develops, when the tumour is small, or now in so many cases when the tumour is in Stage Four. Scientists are testing the value of vaccines for class four negative breast cancer having successfully used it for leukemia and melanoma and other cancers. Sometimes, vaccines are combined with other therapies such as cytokine therapy – but it should be clearly noted that vaccines do work and have so for some time now. Are there side effects of biological therapies? As each person's individual medical profile and diagnosis is different, so is his/her reaction to any vaccine type treatment just as you would have had you had a cold. Side effects may be severe, mild, or absent. In all cases as the body discovers and reacts to an invasive virus the white blood cells go into action almost immediately and as part of the process the temperature of the body will rise as it “burns off” the “non-friendly” invader cells. Be sure to discuss with your cancer care team any/all possible side effects of treatment before the treatment begins as with any other treatment. Side effects of practically all biological therapy, which often mimic flu-like symptoms, vary according to the type of therapy/remedy given and may include the following: · fever · chills · nausea · vomiting · loss of appetite · fatigue Specifically, cytokine therapy often causes fever, chills, aches, and fatigue. Other side effects include a rash or swelling at the injection site. Therapy can cause fatigue and bone pain and may affect blood pressure. A “cytokine” is a natural body protein that acts as regulators of host (patient) and the various levels of responses to infection, immune responses, inflammation, and trauma which for the most part will results in increased body temperature – the body is “reacting” thanks to white blood cells suddenly “getting very busy”. Note: These side effects as sited pale “substantially” in comparison with those side effects experienced by chemotherapy (around since 1943) with a whole host of chemicals which destroy good and bad cells in their path and to varying degree most of which can not be restored, and radiology (burn treatment around since 1886) which also kills good and bad cells all the way through the body including the tell-tale burn on the skin front and back. Surgery – for biopsies yes … As a cancer treatment definitely not. (Hell just lop it off – right?) In all too many cases this vastly out-dated form of cancer “treatment” allows for the recurrence of cancer and so weakening the body’s auto-immune system (white blood cells combined with cytokines) to such a point that the patient will surfer a recurrence of the same and or other forms of cancer 40% of the time – especially the very young and the very old. So - Your choice now is very simple – this is a defining moment - both you the private citizen and the private corporation can decide who and what to fund. The ethics are also simple – choose “inept” or “adept”. The larger labs have failed us – thought they can replicate us; the larger cancer raising programs have failed because they failed to finance the smaller labs. It’s the story of the small Dr. Banting lab which discovered insulin so many years ago all over again. But now you know, thankfully to the internet. This is a private sector initiative. The Government will catch up only when it decides to do so. They are always late to the table. It’s your choice now, whether this takes three years, whether it takes four years, whether it takes five years; and how many more have to die from cancer when they don’t have to. And due to current financial restrictions you will not find this arriving at your front door as a solicitation letter. This is it. Like everything else we do, we are only using modern technology. Your financial support for the Macklin Medical Mission would be sincerely appreciated. Thank you. Eric J. Macklin MBA., FICB, FCSI, FMA, UE Director Macklin Medical Mission [Est. 1886] Chairman The Nancy-Griffon Foundation Inc [Est. 1975] See us at: www.thenancygriffonfund.com Youtube: Breast Cancer - A New Direction Facebook: www.facebook.com/eric.macklin Twitter: http://twitter.com/beowolfe1 And: http://www.gofundme.com/2q7rfk Addendum For those of you in the computer industry think of bio-logics as compu-logics with white blood cells and T-cells as micro-bytes. Additionally I ask you to think of cancer in its many forms a variation on a theme much like the computer industry, in this case in terms of real life – Grand Theft Cancer as in pretend life – Grand Theft Auto. By extension in this comparison it will take the same amount of money and technicians to develop a cancer vaccine program for just one type of cancer (game of life) which is about $500 million and similarly for a computer program (pretend game of life) like Grand Theft Auto at $280 million. The cancer vaccines in all their variations will be sold for $200 to $300 per patient once in general use much like games are sold at $65 each to recover their research and development costs. In this case vaccines will outsell games 100 to one. Something to think about in the very near future.